T. L. Schultz

A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs

This study uses the AsGM1 membrane lipid signature to distinguish NK cells and ILC1s, capturing their plasticity across tissues and conditions.

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors

This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.

Acquisition of Host Cytosolic Protein by Toxoplasma gondii Bradyzoites

This study shows that Toxoplasma gondii bradyzoites can internalize host-derived cytosolic mCherry across the cyst wall.

Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

This study develops an orally bioavailable prodrug of ELQ-316 that enhances its plasma concentrations and efficacy against Toxoplasma gondii infection.

The IRE1α stress signaling axis is a key regulator of neutrophil antimicrobial effector function

The paper shows that IRE1α activation enhances neutrophil antimicrobial functions like IL-1β production, NET formation, and MRSA killing.

A role for Toxoplasma gondii chloroquine resistance transporter in bradyzoite viability and digestive vacuole maintenance

This study shows that the Toxoplasma gondii chloroquine resistance transporter (TgCRT) is essential for maintaining the digestive vacuole and bradyzoite viability, suggesting it as a potential target for treating chronic Toxoplasma infection.