B. L. Pentelute

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

This paper uses machine learning to design cytotoxic T cell epitopes by modeling proteasomal degradation scores and testing their immunogenicity.

In-cell penetration selection-mass spectrometry produces noncanonical peptides for antisense delivery

This paper develops in-cell PS-MS to discover synthetic peptides for delivering macromolecules to the cytosol, identifying Pep1a as a highly effective peptide for antisense delivery.

Cell-Penetrating D-Peptides Retain Antisense Morpholino Oligomer Delivery Activity

The paper shows that D-peptides can deliver antisense morpholino oligomers as effectively as L-peptides while being more stable in serum.

De Novo Discovery of High Affinity Peptide Binders for the SARS-CoV-2 Spike Protein

This paper identifies high-affinity peptide binders for the SARS-CoV-2 spike protein using affinity selection-mass spectrometry, with nanomolar affinities and selectivity over human serum proteins.

Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides

The paper identifies a D-peptide that targets murine erythrocytes and reduces anti-drug antibody responses when conjugated to therapeutic proteins.

Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD

This study investigates ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD using molecular dynamics simulations and peptide synthesis, finding that a 23-mer peptide fragment binds with micromolar affinity to insect-derived RBD but not HEK-expressed RBD.

Mutations in pmrB confer cross-resistance to the LptD inhibitor POL7080 and colistin in Pseudomonas aeruginosa

The paper identifies mutations in pmrB conferring cross-resistance to POL7080 and colistin in Pseudomonas aeruginosa by linking resistance mechanisms to lipid A modifications.