Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium
A. M. Hogan, A. Natarajan, D. T. Maydaniuk, B. Leon, Z. Batun, A. Motnenko, A. Bosch, S. T. Cardona
This study identifies cell envelope-associated resistance and susceptibility determinants in Burkholderia cenocepacia using transposon mutagenesis and antibiotic profiling, revealing new vulnerabilities to β-lactams and the mechanism of cefiderocol.
Nature Communications · Aug 9, 2023Peer-reviewedMicrobiology