Notch-Induced Endoplasmic Reticulum-Associated Degradation Governs Thymocyte β-Selection
X. Chen, X. Liu, J. Yu, L. Xu, K. Umphred-Wilson, F. Peng, Y. Ding, B. M. Barton, X. Lv, M. Y. Zhao, S. Sun, Y. Hong, L. Qi, S. Adoro
This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.
bioRxiv · May 6, 2021Immunology