Author

B. Nagar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

F. Hussain· 2 shared U. D. Akavia· 2 shared A. Gorelik· 1 shared A. Palmigiano· 1 shared A. V. Pshezhetsky· 1 shared B. Amilhon· 1 shared B. Bigger· 1 shared C. J. Cameron· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

F. Hussain

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

T. Xu, R. Heon-Roberts, T. Moore, P. Dubot, X. Pan, T. Guo, C. W. Cairo, R. Holley, B. Bigger, T. Durcan, T. Levade, J. Ausseil, B. Amilhon, A. Gorelik, B. Nagar, , A. V. Pshezhetsky

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

bioRxiv · Apr 26, 2024 · PreprintBiochemistry

Receptor Mediated Delivery of Cas9-Nanobody Induces Cisplatin Synthetic Dose Sensitivity

P. Roche, H. Gytz Olesen, F. Hussain, Y. Liang, N. Stub Laursen, K. R. Andersen, B. Nagar, U. D. Akavia

This study demonstrates receptor-mediated delivery of Cas9-Nanobody to A549 cells, enhancing cisplatin sensitivity through synthetic dose lethality.

bioRxiv · Aug 9, 2018 · PreprintBiochemistry

Homology Directed Repair by Cas9:Donor Co-localization in Mammalian Cells

P. J. Roche, H. Gytz, F. Hussain, C. J. Cameron, D. Paquette, M. Blanchette, J. Dostie, B. Nagar, U. D. Akavia

The paper improves HDR efficiency in mammalian cells using Cas9 fused to a monoavidin domain and PEI delivery, achieving up to 90% HDR in three loci.

bioRxiv · Aug 6, 2018Biochemistry