Author

B. Bigger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. D. Adamson· 1 shared A. Gorelik· 1 shared A. Hoyle· 1 shared A. Palmigiano· 1 shared A. Pickard· 1 shared A. V. Pshezhetsky· 1 shared B. Amilhon· 1 shared B. C. Calverley· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

A. D. Adamson

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Collagen fibril formation at the plasma membrane occurs independently from collagen secretion

A. Pickard, R. Garva, A. D. Adamson, B. C. Calverley, A. Hoyle, C. Hayward, D. Spiller, Y. Lu, N. W. Hodson, O. Mandolfo, K. Kim, G. Bou-Charios, J. Swift, B. Bigger, K. E. Kadler

The paper investigates collagen fibril formation in fibroblasts, showing it occurs at the plasma membrane independently of secretion and involves endocytosis.

bioRxiv · May 9, 2024Cell Biology

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

T. Xu, R. Heon-Roberts, T. Moore, P. Dubot, X. Pan, T. Guo, C. W. Cairo, R. Holley, B. Bigger, T. Durcan, T. Levade, J. Ausseil, B. Amilhon, A. Gorelik, B. Nagar, , A. V. Pshezhetsky

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

bioRxiv · Apr 26, 2024 · PreprintBiochemistry