Compartment-driven imprinting of intestinal CD4 (regulatory) T cells in inflammatory bowel disease and homeostasis
L. Lutter, J. J. M. ter Linde, E. C. Brand, D. P. Hoytema van Konijnenburg, B. Roosenboom, C. Horjus Talabur-Horje, B. Oldenburg, F. van Wijk
The paper examines CD4 T cell changes in inflammatory bowel disease, finding compartment-specific transcriptional programming driven by regulators like ARID4B and SATB1, with epithelial translocation dampening pro-inflammatory responses.
bioRxiv · May 6, 2022 · PreprintImmunology