W. Ying

Chemical inhibition of PIN auxin transporters by the anti-inflammatory drug Naproxen

This study identifies Naproxen as a chemical inhibitor of PIN auxin transporters in plants, revealing its mechanism of action through cellular, biochemical, and structural analyses.

Koisio Technology-Modulated Cell Culture Media can Significantly Increase the Antioxidant Capacity of Mouse Fibroblasts

This study shows that Koisio technology-modulated cell culture media enhance mouse fibroblasts' antioxidant capacity against H2O2-induced stress without adding external substances.

Differential Effects of Koisio Technology-Modulated Solutions on the Growth of Lung Fibroblast Cell Cultures and Lung Cancer Cell Cultures

This study shows Koisio technology-modulated solutions increase lung fibroblast growth by 20% and decrease lung cancer cell growth by 9%, with fibroblasts also showing 14% longer telomeres.

Koisio Technology-Modulated Cell Culture Media can Lead to Markedly Increased Intracellular ATP Levels of Fibroblast Cell Cultures

This study shows that Koisio-modulated cell culture media increases intracellular ATP levels in L929 fibroblasts without affecting mitochondrial membrane potential.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

SSR1 is a vital regulator in plant mitochondrial iron-sulfur biosynthesis

This study identifies SSR1 as a chaperone-like protein that enhances HSCA2-ISU1 interaction in the mitochondrial iron-sulfur cluster biosynthesis pathway, essential for plant mitochondrial function.

Intracellular Oxidative Stress Levels are Significantly Associated with the Green Autofluorescence Intensity of Buthionine Sulfoximine-Treated B16-F10 Cells

This study shows that green autofluorescence intensity in B16-F10 cells correlates with intracellular oxidative stress and cell death induced by BSO.

Epidermal Green Autofluorescence is A Novel Biomarker for Local Inflammation of the Skin

The paper identifies epidermal green autofluorescence as a novel non-invasive biomarker for detecting local skin inflammation using a mouse model.

Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

Inflammation mediates lung cancer-induced increase in the epidermal green autofluorescence of mice

This study investigates how lung cancer increases epidermal green autofluorescence in mice and finds that inflammation is the key driver of this increase.

Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in PC12 cells

This study shows oxidative stress reduces Nampt mRNA and protein levels in PC12 cells, contributing to cell death and NAD+ deficiency.

Selectively increased autofluorescence at certain regions of skin may become a novel diagnostic biomarker for lung cancer

This study shows increased epidermal green autofluorescence in skin and nails of lung cancer patients and mice, suggesting it as a potential non-invasive diagnostic biomarker.

A fast numerical method for oxygen supply in tissue with complex blood vessel network

The paper introduces a fast numerical method for simulating oxygen supply in tissue with complex blood vessel networks, achieving accurate results efficiently.

A Mild Keratin 1 Decrease Leads to Cell Death and Increased Oxidative Stress in B16-F10 Melanoma Cell Lines

This study shows that reducing keratin 1 in B16-F10 melanoma cells causes cell death and increased oxidative stress, suggesting K1 as a potential therapeutic target.

Adipose tissue macrophages orchestrate β cell adaptation in obesity through secreting miRNA-containing extracellular vesicles

This study shows that adipose tissue macrophage-derived extracellular vesicles containing miRNA-155 regulate β cell function and proliferation in obesity.

The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.

Mitochondrial Electron Transport Chain Inhibition Suppresses LPS-Induced Inflammatory Responses via TREM1/STAT3 Pathway in BV2 Microglia

This study shows that mitochondrial ETC inhibitors suppress LPS-induced inflammation in BV2 microglia by reducing TREM1 and p-STAT3/STAT3 ratios.

Epidermal green autofluorescence intensity is significantly associated with the serum levels of multiple cytokines of LPS-exposed mice

The paper investigates the association between epidermal green autofluorescence intensity and serum cytokine levels in LPS-exposed mice, finding significant correlations with multiple inflammatory and anti-inflammatory cytokines.

Lipopolysaccharide (LPS) induces increased epidermal green autofluorescence of mouse

This study shows that LPS induces dose-dependent increases in epidermal green autofluorescence in mice, suggesting it as a potential biomarker for systemic inflammation.

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

This study identifies green autofluorescence intensity in fingernails and skin regions as a non-invasive biomarker for assessing blood vessel health and risk of stroke or myocardial infarction.

Professional Swimmers and Normal Populations have Different Patterns of Epidermal Green Autofluorescence

This study finds professional swimmers have higher green autofluorescence intensity and asymmetry in specific skin regions compared to age-matched controls, suggesting increased oxidative stress and inflammation.

The green autofluorescence intensity and asymmetry of older men is significantly higher than those of older women in their fingernails and certain regions of skin

The study finds that older men have higher green autofluorescence intensity and asymmetry in fingernails and skin compared to older women, suggesting potential gender-based biomarkers.

NAD+ treatment can increase directly the antioxidant capacity of rotenone-treated differentiated PC12 cells

This study shows NAD+ treatment increases antioxidant capacity in rotenone-treated PC12 cells by raising the GSH/GSSG ratio, suggesting a direct mechanism for its protective effects against oxidative stress.

SIRT2, ERK and Nrf2 mediate NAD+ treatment-induced increase in the antioxidant capacity of differentiated PC12 cells under basal conditions

This study shows NAD+ increases antioxidant capacity in PC12 cells through SIRT2, ERK, and Nrf2 pathways under basal conditions.

Extracellular Degradation into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-produced increases in the Adenylate Pool of BV2 Microglia under Basal Conditions

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.