K. Tang

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Addressing Artemisinin Resistance in Malaria Treatment: A Novel Ferrous ACT (FACT) Formulation

This paper proposes a new ACT formulation (ferrous ACT) that combines traditional ACT with iron supplements to address artemisinin resistance in malaria.

CSTA: A Biomarker Regulating Esophageal Stricture Epithelial Barrier, Potential Medication Target

The paper identifies CSTA as a biomarker for esophageal epithelial barrier function and shows FK506 can rescue CSTA-knockdown effects in strictures.

Cladosporium species detoxify multiple water micropollutants of emerging concern using diverse strategies

This study identifies Cladosporium species as effective in detoxifying multiple water micropollutants through diverse strategies, including oxidation, methylation, and carboxylation.

Immunities Specific to Both of the M Protein Ectodomain and RBD Synergize to Confer Cross-protection against SARS-CoV-2 Infections

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

Engineering and implementation of synthetic molecular tools in the basidiomycete fungus Ustilago maydis

This study implements and characterizes synthetic molecular tools in Ustilago maydis for improved reporter gene expression and in planta detection of fungal infection.

Human Early Syncytiotrophoblasts Are Highly Susceptible to SARS-CoV-2 Infection

This paper shows that human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection via ACE2 and demonstrates antiviral efficacy of remdesivir and GC376.

Perturbation of mitochondrial Ca2+ homeostasis activates cross-compartmental proteostatic response in Arabidopsis

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

Dual control of lysogeny and phage defense by a phosphorylation-based toxin/antitoxin system

This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

Chromogranin A plays a crucial role in the age-related development of insulin resistance and hypertension

This study shows that Chromogranin A deficiency in mice prevents age-related insulin resistance and hypertension, with hypertension reversing spontaneously as mice age.

An Aerobic Anoxygenic Phototrophic Bacterium Fixes CO2 via the Calvin-Benson-Bassham Cycle

The paper identifies a novel aerobic anoxygenic phototrophic bacterium, strain B3, capable of photoautotrophy via the Calvin-Benson-Bassham cycle using sulfite or H2 as electron donors.

A H3K9me2-Binding Protein AGDP3 Limits DNA Methylation and Transcriptional Gene Silencing in Arabidopsis

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

Catestatin regulates the colonic mucus layer in inflammatory bowel disease

This study shows that catestatin (CST) regulates the colonic mucus layer in IBD, with CST levels elevated in IBD patients and CST-KO mice showing increased mucus thickness.

Catestatin induces glycogenesis by stimulating phosphoinositide 3-kinase-AKT pathway

This study shows that Catestatin increases hepatic glycogen synthesis in insulin-resistant mice by enhancing insulin signaling through the phosphoinositide 3-kinase-AKT pathway.

Dysfunction of the histone demethylase IBM1 in Arabidopsis reshapes the root-associated bacteria community

This study shows that dysfunction of IBM1 in Arabidopsis changes root-associated bacteria communities by altering microbial family abundances in both rhizosphere and endosphere.

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

Targeted Genome Editing of Bacteria Within Microbial Communities

This paper develops a method to edit specific bacteria within microbial communities using ET-Seq and DART systems, enabling genetic manipulation in complex environments.

The immunosuppression of macrophages underlies the cardioprotective effects of catestatin (CST)

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.

Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction

This study shows that eosinophil deficiency after myocardial infarction leads to adverse cardiac remodeling, which can be mitigated by IL-4 therapy.