S. El Aidy

This study constructs a synthetic small intestinal microbiota community to investigate how probiotics alter metabolic activity and colonization resistance in a probiotic-specific manner.

This study shows how probiotic supplementation to adult human small intestinal stoma microbiota alters nutrient utilization and resistance to perturbations through changes in metabolite production.

This study shows that gut microbiota transplantation from CST-KO mice to wild-type mice induces colonic fibrosis and tight junction impairment, suggesting a causal role for microbiota in intestinal dyshomeostasis linked to catestatin deficiency.

This study shows that catestatin (CST) alters gut microbiota composition and promotes antimicrobial resistance in CST-KO mice, with implications for inflammatory bowel disease.

This study shows that Parkinson's disease medications reduce small intestinal motility and alter microbiota composition in rats, mirroring human PD microbiota changes.

This paper reviews how flux balance analysis can be used to study host-microbe interactions in the gut through in silico simulations of metabolic networks.

This study shows that loss of C3aR in a mouse model of colon cancer leads to immune infiltration and inflammatory microbiota changes.

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

This study shows that pH-dependent spontaneous hydrolysis, not gut bacterial metabolism, reduces methylphenidate levels, affecting its bioavailability.

This study shows that gut bacteria deaminate levodopa, a Parkinson's disease medication, and identifies the enzyme responsible, with implications for drug effectiveness and side effects.