SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex
L. L. Lin, X. Wei, H. H. Wang, B. Pederson, M. Torres, Y. Lu, Z. J. Li, X. Liu, H. Mao, H. Wang, Z. Zhao, S. E. Sun, L. Qi
This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.
bioRxiv · Apr 13, 2023 · PreprintBiochemistry