Author

H. Mao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 2 Bioengineering· 2 Pathology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Approach:deep learning· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:dimensionality reduction· 3 Assay:fluorescence / live-cell microscopy· 3 Research Focus:host-pathogen & immune response· 3 Assay:imaging· 3

Frequent Co-Authors

L. Chen· 4 shared H. Li· 3 shared J. Tan· 3 shared S. Zhao· 3 shared W. Zhao· 3 shared X. Wang· 3 shared Y. Hu· 3 shared B. S. Ahluwalia· 2 shared

Activity by Year

2018-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiophysics

L. Chen

Mutual co-authors in cluster

Author profile →

16 papers

Recent·Most cited

Inter-domain flexibility in F-Box proteins revealed by integrative modeling

B. Shor, F. Jiao, H. Shi, H. Mao, C. Yu, M. Braitbard, L. Huang, N. Zheng, Dina Schneidman-Duhovny

The paper uses integrative modeling to reveal inter-domain flexibility in F-box proteins, showing varying conformational dynamics across different F-box proteins.

bioRxiv · Nov 9, 2026 · PreprintMolecular Biology

Panax ginseng enhances the effect of metoprolol in chronic heart failure by inhibiting autophagy

N. Zichang, H. Xiaoling, L. Ting, J. Qi, O. Minghui, H. Mao

This study shows that Panax ginseng combined with metoprolol improves survival and heart function in HF mice by inhibiting autophagy via the PI3K/Akt/mTOR pathway.

bioRxiv · Mar 26, 2024 · PreprintPharmacology & Toxicology

Self-inspired learning to denoise for live-cell super-resolution microscopy

L. Qu, S. Zhao, Y. Huang, X. Ye, K. Wang, Y. Liu, X. Liu, H. Mao, G. Hu, W. Chen, C. Guo, J. He, J. Tan, H. Li, L. Chen, W. Zhao

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

bioRxiv · Jan 23, 2024Bioengineering

Super-resolution histology of paraffin-embedded samples via photonic chip-based microscopy

L. E. Villegas-Hernandez, V. K. Dubey, H. Mao, M. Pradhan, J.-C. Tinguely, D. H. Hansen, S. Acuna, B. Zapotoczny, K. Agarwal, M. Nystad, G. Acharya, K. A. Fenton, H. E. Danielsen, B. S. Ahluwalia

This paper introduces a photonic chip-based microscopy method for super-resolution imaging of FFPE tissue sections, demonstrating improved contrast and compatibility with histological workflows.

bioRxiv · Jun 14, 2023 · PreprintPathology

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex

L. L. Lin, X. Wei, H. H. Wang, B. Pederson, M. Torres, Y. Lu, Z. J. Li, X. Liu, H. Mao, H. Wang, Z. Zhao, S. E. Sun, L. Qi

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

bioRxiv · Apr 13, 2023 · PreprintBiochemistry

Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure

H. Mao, K. Szafranska, L. Kruse, C. Holte, D. L. Wolfson, B. S. Ahluwalia, C. B. Whitchurch, L. Cole, G. P. Lockwood, R. Diekmann, D. G. Le Couteur, V. C. Cogger, P. A. G. McCourt

The paper examines the effects of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure, finding no toxic effects but changes in fenestration frequency and porosity at high concentrations.

bioRxiv · Jan 20, 2023Cell Biology

Enhancing detectable fluorescence fluctuation for high-throughput and four-dimensional live-cell super-resolution imaging

W. Zhao, S. Zhao, Z. Han, X. Ding, G. Hu, X. Wang, H. Mao, Y. Jiu, Y. Hu, J. Tan, X. Ding, C. Guo, L. Chen, H. Li

This paper introduces SACD, a super-resolution imaging method that reduces acquisition time and improves resolution, enabling high-throughput and 4D live-cell imaging.

bioRxiv · Dec 12, 2022Biophysics

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

W. Zhao, X. Huang, J. Yang, G. Qiu, L. Qu, Y. Zhao, S. Zhao, Z. Luo, X. Wang, Y. Jiu, H. Mao, X. Ding, J. Tan, Y. Hu, L. Pan, , H. Li

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

bioRxiv · Dec 1, 2022Biophysics

Structured illumination microscopy artifacts caused by illumination scattering

Y. Mo, F. Feng, H. Mao, J. Fan, L. Chen

This study investigates SIM artifacts caused by light scattering in thick samples and shows how sample thickness affects 2D-SIM image reconstruction.

bioRxiv · Jan 1, 2021Biophysics

The NMR structure of a vestigial nuclease provides insight into the evolution of functional transitions in viral dsDNA packaging motors

B. P. Mahler, P. J. Bujalowski, H. Mao, E. A. Dill, P. J. Jardine, K. H. Choi, M. Morais

The paper reports the NMR structure of a vestigial nuclease domain in phi29 ATPase, revealing its evolutionary origin and role in DNA packaging motor function.

Nucleic Acids Research · Nov 18, 2020Peer-reviewedBiophysics

Developing Commotio Cordis Injury Metrics by Correlating Chest Force and Rib Deformation to Left Ventricle Strain and Pressure

G. J. Dickey, K. Bian, H. R. Khan, H. Mao

This study correlates chest force and rib deformation to left ventricle strain and pressure in commotio cordis, finding that rib deformations over the LV are strongly correlated to LV strain.

bioRxiv · Oct 28, 2020Bioengineering

Loss of Bone Morphogenetic Protein-binding Endothelial Regulator Causes Insulin Resistance

H. Mao, L. Li, Q. Fan, A. Angelini, P. K. Saha, H. Wu, C. M. Ballantyne, S. M. Hartig, L. Xie, X. Pi

This study shows BMPER deficiency leads to insulin resistance and hyperglycemia, and BMPER therapy improves these conditions in mice.

bioRxiv · Jun 4, 2020Pathology

ITPK1-Dependent Inositol Polyphosphates Regulate Auxin Responses in Arabidopsis thaliana

N. P. Laha, Y. W. Dhir, R. F. H. Giehl, E. M. Schaefer, P. Gaugler, Z. H. Shishavan, H. Gulabani, H. Mao, N. Zheng, N. von Wiren, H. J. Jessen, A. Saiardi, S. Bhattacharjee, D. Laha, G. Schaaf

This study shows that ITPK1 produces 5-InsP7, which binds to auxin receptors and influences plant growth responses.

bioRxiv · Apr 23, 2020 · PreprintPlant Biology

Rapid development of an inactivated vaccine for SARS-CoV-2

Q. Gao, L. Bao, H. Mao, L. Wang, K. Xu, m. Yang, Y. Li, L. Zhu, N. Wang, Z. Lv, H. Gao, X. Ge, B. Kan, Y. Hu, J. Liu, , C. Qin

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

bioRxiv · Apr 17, 2020Microbiology

Electrospun Ag-doped SnO2 hollow nanofibers with high antibacterial activity

Y. Li, X. Tang, B. Zhang, H. Mao

This study fabricates Ag-doped SnO2 hollow nanofibers and demonstrates that silver doping enhances their antibacterial activity compared to pure SnO2.

bioRxiv · May 7, 2019Biochemistry

Natural selection on TMPRSS6 associated with the blunted erythropoiesis and improved blood viscosity in Tibetan Pigs

X. Kong, X. Dong, S. Yang, J. Qian, J. Yang, Q. Jiang, X. Li, B. Wang, D. Yan, S. Lu, H. Mao, X. Gou

This study identifies a deletion in TMPRSS6 associated with reduced hemoglobin and improved blood viscosity in Tibetan pigs adapted to high altitude.

bioRxiv · Jul 30, 2018Physiology