Author

J. Dhillon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. El-Kenawi· 3 shared B. J. Manley· 2 shared B. Ruffell· 2 shared J. Chahoud· 2 shared N. H. Chakiryan· 2 shared A. Anderson· 1 shared A. Aydin· 1 shared A. Berglund· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

A. El-Kenawi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak, O. E. Ospina, N. H. Chakiryan, A. E. Berglund, P. A. Stewart, J. V. Nguyen, C. M. M. Segura, N. L. Francis, P. M. R. Echevarria, J. Chahoud, R. Li, K. Y. Tsai, J. A. Blasi, , B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

bioRxiv · Nov 16, 2023Cancer Biology

Mass Recovery following Caloric Restriction Reverses Lipolysis and Proteolysis, but not Gluconeogenesis, in Insulin Resistant OLETF Rats

M. A. Cornejo, J. Dhillon, A. Nishiyama, D. Nakano, R. M. Ortiz

This study examines how caloric restriction and subsequent mass recovery affect substrate metabolism in insulin-resistant rats, finding that lipolysis and proteolysis are reversed, but gluconeogenesis remains unchanged.

bioRxiv · May 17, 2021Physiology

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

A. El-Kenawi, W. Dominguez-Viqueira, M. Liu, S. Awasthi, A. Keske, K. K. Steiner, L. Noel, J. Dhillon, R. J. Gillies, K. Yamoah, X. Yu, J. Koomen, R. A. Gatenby, B. Ruffell

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

bioRxiv · Mar 24, 2021Cancer Biology

Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma

N. H. Chakiryan, G. Kimmel, Y. Kim, A. Hajiran, A. Aydin, L. Zemp, E. Katende, J. Nguyen, N. Lopez-Blanco, J. Chahoud, P. Spiess, M. Fournier, J. Dhillon, L. Wang, C. Moran-Segura, , B. J. Manley

The paper quantifies cellular density and clustering of immune cells in metastatic ccRCC and finds that CD68+ TAM clustering with tumor cells correlates with worse overall survival.

bioRxiv · Jan 4, 2021Cancer Biology

Acidity promotes tumor progression by altering macrophage phenotype in prostate cancer

A. El-Kenawi, C. Gatenbee, M. Robertson-Tessi, R. Bravo, J. Dhillon, Y. Balagurunathan, A. Berglund, N. Visvakarma, A. Ibrahim-Hashim, J. Choi, K. Luddy, R. Gatenby, S. P. Thomas, A. Anderson, B. Ruffell, R. Gillies

This study shows that tumor acidity promotes prostate cancer by altering macrophage phenotype, both in vitro and in vivo, and is supported by in silico modeling.

bioRxiv · Nov 26, 2018Immunology