ATF4 Dependent Increase in Mitochondrial-Endoplasmic Reticulum Tethering Following OPA1 Deletion in Skeletal Muscle
A. Hinton, P. Katti, M. Mungai, D. Hall, O. Koval, J. Shao, Z. Vue, E. G. Lopez, R. Rostami, K. Neikirk, J. Ponce, J. Streeter, B. Schickling, S. Bacevac, C. Grueter, , E. D. Abel
This study shows that OPA1 deficiency in skeletal muscle increases MERC formation via ATF4, affecting calcium exchange and mitochondrial-ER tethering.
bioRxiv · Sep 12, 2022Biophysics