Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide
L. Qi, Q. Luo, Y. Hou, Y. Xu, W. Yu, X. Liu, B. Xin, Y. Huang, X. Li, Y. Zhang, S. Wang, P. Sadler, Y. Zhao, F. Wang
This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.
bioRxiv · Feb 28, 2024Cancer Biology