Author

J. E. Dick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 10 Cell Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 14 Research Focus:cell type annotation· 11 Approach:experimental assay· 9 Approach:statistical model· 8 Research Focus:differential expression· 7 Assay:scRNA-seq· 7 Research Focus:gene regulatory network inference· 6 Assay:bulk RNA-seq· 5

Frequent Co-Authors

A. G. X. Zeng· 7 shared A. Murison· 7 shared M. D. Minden· 7 shared V. Voisin· 6 shared E. Wagenblast· 5 shared O. I. Gan· 5 shared S. Z. Xie· 5 shared A. Mitchell· 4 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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7 shared papersCancer Biology

A. G. X. Zeng

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

J. L. Araujo, E. Wagenblast, V. Voisin, J. McLeod, O. I. Gan, S. Bansal, L. Jin, A. Mitchell, B. Gratton, S. Cutting, A. Arruda, M. Doedens, J.-M. Capo-Chichi, S. Abelson, M. D. Minden, , J. E. Dick

This study shows FLT3 is essential for ITD-mutated leukemic stem cells but not for normal hematopoietic stem cells, supporting targeted therapies for AML.

bioRxiv · Jun 30, 2024Cancer Biology

Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties

H. Boutzen, A. Murison, J. C. Y. Wang, C. Arlidge, M. Lupien, K. B. Kaufmann, J. E. Dick

The paper identifies two distinct leukemia stem cell subtypes with unique transcriptional, epigenetic, and functional properties using a patient-derived cell model and single-cell analysis.

bioRxiv · Feb 9, 2024Cancer Biology

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

A. G. X. Zeng, I. Iacobucci, S. Shah, A. Mitchell, G. Wong, S. Bansal, D. Chen, Q. Gao, H. Kim, J. A. Kennedy, M. D. Minden, T. Haferlach, C. G. Mullighan, J. E. Dick

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

bioRxiv · Dec 26, 2023Cancer Biology

Single cell dissection of developmental origins and transcriptional heterogeneity in B-cell acute lymphoblastic leukemia

I. Iacobucci, A. G. X. Zeng, Q. Gao, L. Garcia-Prat, P. Baviskar, S. Shah, A. J. Murison, V. Voisin, M. Chan-Seng-Yue, C. Cheng, C. Qu, C. Bailey, M. Lear, M. Witkowski, X. Zhou, , C. G. Mullighan

This study uses scRNA-seq to analyze B-ALL samples, revealing transcriptional heterogeneity and developmental origins, with specific subtypes associated with distinct cell populations and clinical outcomes.

bioRxiv · Dec 4, 2023Cancer Biology

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

N. A. Jakobsen, S. Turkalj, A. G. X. Zeng, B. Stoilova, M. Metzner, M. S. Nagree, S. Shah, R. Moore, B. Usukhbayar, M. A. Salazar, G.-A. Gafencu, A. Kennedy, S. Newman, B. J. L. Kendrick, A. H. Taylor, , P. Vyas

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

bioRxiv · Sep 12, 2023 · PreprintCancer Biology

Identification of a human hematopoietic stem cell subset that retains memory of inflammatory stress

A. G. X. Zeng, M. S. Nagree, N. A. Jakobsen, S. Shah, A. Murison, J.-G. Cheong, S. Turkalj, I. Lim, L. Jin, J. Araujo, A. G. Aguilar-Navarro, D. Parris, J. McLeod, H. Kim, H. S. Lee, , S. Z. Xie

The paper identifies a human HSC subset with inflammatory memory that accumulates with age and clonal hematopoiesis, potentially increasing cancer and infection risks.

bioRxiv · Sep 11, 2023 · PreprintCell Biology

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing

T. Itkin, S. Houghton, R. Schreiner, Y. Lin, C. Badwe, V. Voisin, A. Murison, N. Seyedhassantehrani, K. B. Kaufmann, L. Garcia-Prat, G. T. Booth, F. Geng, Y. Liu, J. M. Gomez-Salinero, J.-H. Shieh, , S. Rafii

The paper identifies Fli-1's role in regulating HSC activation during regenerative hematopoiesis by enabling niche signaling and functional recovery.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

C. S. Johnson, K. Sham, S. Belluschi, X. Wang, W. Lau, K. B. Kaufmann, G. Krivdova, E. F. Calderbank, N. Mende, J. McLeod, G. Mantica, M. J. Williams, C. Grey-Wilson, M. Drakopoulos, S. Sinha, , E. Laurenti

This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.

bioRxiv · Nov 17, 2022 · PreprintCell Biology

KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

L. D. Boila, S. Ghosh, S. K. Bandyopadhyay, L. Jin, A. Murison, A. G. X. Zeng, W. Shaikh, S. Bhowmik, S. S. N. A. Muddineni, M. Biswas, S. Sinha, S. S. Chatterjee, N. Mbong, O. I. Gan, A. Bose, , A. Sengupta

This study shows that KDM6A loss in AML increases sensitivity to PARP and BCL2 inhibitors, suggesting a new combination therapy approach for KDM6A-mutant AML.

bioRxiv · Jul 12, 2022 · PreprintCancer Biology

A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target

A. Vujovic, L. P. M. H. de Rooij, A. Keyvani Chahi, H. T. Chen, B. Yee, S. K. Loganathan, L. Liu, D. C. H. Chan, A. Tajik, E. Tsao, S. Moreira, P. Joshi, J. Xu, N. Wong, S. Zandi, , K. J. Hope

This study identifies RNA binding proteins essential for leukemic stem cell survival using an in vivo CRISPR screen and highlights ELAVL1 as a therapeutic target in AML.

bioRxiv · Jun 11, 2022 · PreprintCancer Biology

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML

A. G. X. Zeng, S. Bansal, L. Jin, A. Mitchell, W. C. Chen, H. A. Abbas, M. Chan-Seng-Yue, V. Voisin, P. van Galen, A. Tierens, M. Cheok, C. Preudhomme, H. Dombret, N. Daver, P. A. Futreal, , J. E. Dick

This study identifies a cellular hierarchy framework in AML that links disease heterogeneity with drug response and develops a 7-gene biomarker predictive of drug sensitivity.

bioRxiv · Jan 25, 2022Cancer Biology

Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML

G. Krivdova, V. Voisin, E. M. Schoof, S. A. Marhon, A. J. Murison, J. L. McLeod, M. Gabra, A. G. Zeng, E. L. Van Nostrand, S. J. Aigner, A. A. Shishkin, B. A. Yee, K. G. Hermans, A. G. Trotman-Grant, N. Mbong, , E. R. Lechman

This study identifies miR-130a as a regulator of HSC self-renewal and differentiation, with TBL1XR1 as a key target, and shows its role in maintaining the oncogenic program in t(8;21) AML.

bioRxiv · Jul 30, 2021Cell Biology

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

J. F. Woolley, K. Chen, G. T. Saffi, G. E. Genc, D. K. C. Lee, I. Dzneladze, R. He, J. T.-S. Chow, M. M. Gabra, M. H. Son, C. M. P. Melo, C. A. Newell, A. He, E. M. Schoof, S. Z. Xie, , L. Salmena

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

bioRxiv · Mar 25, 2021 · PreprintCancer Biology

Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

L. Garcia-Prat, K. B. Kaufmann, F. Schneiter, V. Voisin, A. Murison, J. Chen, M. Chan-Seng-Yue, O. I. Gan, J. L. McLeod, S. A. Smith, M. C. Shoong, D. Parris, K. Pan, A. G. X. Zeng, G. Krivdova, , J. E. Dick

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

bioRxiv · Feb 24, 2021 · PreprintCell Biology

Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome

E. Wagenblast, J. Araujo, O. I. Gan, S. K. Cutting, A. Murison, G. Krivdova, M. Azkanaz, J. L. McLeod, S. A. Smith, S. A. Marhon, M. Gabra, M. Chan-Seng-Yue, L. Garcia-Prat, L. Salmena, D. D. D. De Carvalho, , E. R. Lechman

This study identifies the cellular origin and mechanisms of leukemia predisposition in Down syndrome by analyzing gene mutations and their effects in fetal hematopoietic cells.

bioRxiv · Nov 29, 2020Cancer Biology