M. M. Savitski

This study examines how drug treatment affects gut microbiota communities, finding that cross-protection is more common than cross-sensitization, and that metabolic processes contribute to these community behaviors.

This study demonstrates that modulating transient interactions in influenza A virus condensates is more effective for hardening than temperature or concentration changes, offering a strategy for antiviral drug design.

The paper investigates how cellular stress triggers reactivation of persistent mumps virus infection through molecular and structural changes in viral condensates.

This study systematically tests drug combinations in Gram-positive bacteria, identifying many new synergies and antagonisms, including effective combinations against drug-resistant strains.

The paper develops ppTPP to study mitochondrial dysfunction's effects on proteome stability and abundance, revealing group-specific response patterns in eukaryotic cells.

The paper uses metabolic labeling and PTM-specific enrichment to reveal the temporal order of phosphorylation events during protein maturation, not protein stability.

The paper presents a high-resolution cryo-EM structure of the ESX-5 Type VII secretion system hexameric pore complex, revealing its assembly and potential gating mechanisms.

The paper identifies phage proteins that block or trigger retron toxin/antitoxin systems in bacteria, revealing their role in anti-phage defense.

The paper identifies retrons as a novel family of tripartite toxin/antitoxin systems in bacteria, with the reverse transcriptase and msDNA functioning as antitoxin components.

This paper identifies a dual-mechanism antibiotic, SCH-79797, that kills Gram-negative and Gram-positive bacteria with low resistance and outperforms combination treatments.

The paper maps Salmonella enterica effector-host protein-protein interactions during infection, identifying 421 novel interactions and demonstrating their roles in pathogenesis.

This study identifies NlpI as a scaffold for PG hydrolases in E. coli, forming multi-enzyme complexes that coordinate PG synthesis and hydrolase activity.

The paper identifies Mpd1 as an ERAD factor that interacts with Sec61 and shows that this interaction is required for CPY* ERAD.