Author

C. E. Cunningham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. S. Vizeacoumar· 2 shared Y. Wu· 2 shared A. Chen· 1 shared A. Dmitriev· 1 shared A. Freywald· 1 shared A. Ganapathysamy· 1 shared A. Jing· 1 shared A. Krishnan· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

F. S. Vizeacoumar

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2 papers

Recent·Most cited

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

C. E. Cunningham, F. S. Vizeacoumar, Y. Zhang, L. Kyrylenko, P. Gao, V. Maranda, H. Dong, J. D. Price, A. Ganapathysamy, R. Hari, C. Denomy, S. Both, K. Wagner, Y. Wu, F. Khan, , M. Empting

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Cell Genomics · Jun 1, 2025Peer-reviewedCancer Biology

Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability

A. Jing, F. S. Vizeacoumar, S. Parameswaran, B. Haave, C. E. Cunningham, Y. Wu, R. Arnold, K. Bonham, A. Freywald, J. Han, F. J. Vizeacoumar

The paper identifies early hypoxia-driven transcriptomic changes in TNBC that promote chromosomal instability and microenvironment remodeling, enabling tumor evolution.

bioRxiv · May 29, 2018Cancer Biology