R. Arnold

A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy

This paper identifies a novel HDAC inhibitor, STR-V-53, that effectively targets HCC and enhances immunotherapy responses in mouse models.

CTCF regulates hepatitis B virus cccDNA chromatin topology

This study shows that CTCF regulates HBV cccDNA chromatin topology and nucleosomal positioning, affecting viral transcription.

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.

A CRISPR Knockout Screen Identifies Foxf1 as a Suppressor of Colorectal Cancer Metastasis That Acts Through Reduced mTOR Signalling

Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability

The paper identifies early hypoxia-driven transcriptomic changes in TNBC that promote chromosomal instability and microenvironment remodeling, enabling tumor evolution.

TGF-β induced CXCL13 in CD8+ T cells is associated with tertiary lymphoid structures in cancer

This study identifies CD8+ T cells as a new source of CXCL13, which contributes to tertiary lymphoid structure formation in tumors through TGF-β signaling.