K. Klein

A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

This paper creates a mouse model with a STAT5BN642H mutation to study NK-cell leukemia and finds it leads to both indolent and aggressive forms of the disease.

Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia

This study evaluates CD19 expression in pediatric AML and shows that CD19-directed immunotherapies are effective against CD19+ AML, similar to their efficacy in BCP-ALL.

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

Elucidating the role of water in collagen self assembly by isotopically modulating collagen hydration

This study investigates how water isotopes affect collagen self-assembly by comparing D2O and H2O, finding faster assembly and thinner fibrils in D2O due to reduced hydration.

YgfB increases β-lactam resistance in Pseudomonas aeruginosa by counteracting AlpA-mediated ampDh3 expression

This study identifies YgfB as a regulator that enhances β-lactam resistance in Pseudomonas aeruginosa by inhibiting AlpA-mediated ampDh3 expression.

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.

Three-dimensional Printing of Customized Bioresorbable Airway Stents

This paper develops bioresorbable airway stents using 3D printing and biomedical inks, showing biocompatibility and suitable degradation in rabbits.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

Replication timing alterations in leukemia reflect stable clinically-relevant changes in genome architecture

The paper compares DNA replication timing profiles of BCP-ALL leukemic samples with normal B-lineage differentiation stages to identify clinically relevant features.

Applying CRISPR-based genetic screens to identify drivers of tumor-cell sensitivity towards NK-cell attack

This study uses CRISPR-based screens to identify factors that enhance NK-cell cytotoxicity against tumor cells, finding B7H6 as a key ligand for NKp30.