B. D. Simons

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Human spermatogonial stem cells retain states with a foetal-like signature

This study identifies a foetal-like state 0B in human spermatogonial stem cells that maintains a suppressive transcriptomic program, contrasting with rodent models where this state is not maintained into adulthood.

Human lymphoid-neutrophil/monocyte restriction co-ordinately activates increased proliferation despite parallel heterogeneity in transcriptional changes

The paper identifies shared proliferation acceleration and heterogeneous transcriptional changes during B-lymphoid and neutrophil/monocyte lineage restriction from CD34+ cord blood cells.

Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration

The paper identifies an IL-1β-Notch-Fosl2 axis that regulates differentiation plasticity of airway progenitors during alveolar regeneration.

Defining the transcriptional signature of esophageal-to-skin lineage conversion

This study shows that esophageal epithelial cells can convert to hair follicle identity when exposed to skin stroma, with HIF1a inhibition blocking this transition.

A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium

The paper investigates how mechanical changes in the mouse esophagus regulate the transition to homeostasis by identifying a committed progenitor population through single-cell RNA sequencing and organ stretching experiments.

Visualization of individual cell division history in complex tissues

This paper introduces iCOUNT, a tool to track cell division history in human and mouse tissues, and uses scRNA-seq to analyze molecular consequences of division in neural stem cells.

Stem cell lineage survival as a noisy competition for niche access

The paper develops a stochastic competition model for stem cell niche access and validates it across multiple tissue datasets.

Constrained actin dynamics emerges from variable compositions of actin regulatory protein complexes

The paper shows that heterogeneous actin regulatory complexes can produce stable filopodia-like structures through stochastic dynamics.

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.