C. John

A Novel ex-vivo platform for personalized treatment in metastatic ovarian cancer.

This study develops an ex-vivo platform using rat mesenteric membranes to assess treatment response in ovarian cancer, showing correlation with clinical outcomes.

Large herbivores link plant phenology and abundance in arctic tundra

This study shows that herbivory affects plant phenology and abundance in arctic tundra, linking these dynamics through green-up timing and seasonal abundance patterns.

Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation

This paper shows that Neisseria gonorrhoeae uses sialic acid from the host to modify its surface, which helps it avoid neutrophil activation without needing the complement system.

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

Unbiased antimicrobial resistance detection from clinical bacterial isolates using proteomics

This study presents an unbiased proteomics workflow for detecting bacterial species and antimicrobial resistance proteins from clinical isolates in under 4 hours with high sensitivity and specificity.

A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella

This study identifies host factors involved in Salmonella-induced endosomal remodeling through an RNAi screen, revealing key roles for SNARE complexes, GTPases, and clathrin-coated structures.

Macrophages protect against loss of adipose tissue during cancer cachexia

This study shows that defective myeloid cell-mediated inflammation enhances cachexia in HCC mice, suggesting macrophages protect against fat loss in cancer cachexia.