M. Hensel

Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

This study shows that oral administration of indole-3-acetate reduces liver steatosis and inflammation in mice fed a high-fat diet.

Factors required for adhesion of Salmonella enterica serovar Typhimurium to lettuce (Lactuca sativa)

This study identifies adhesive factors required for Salmonella enterica serovar Typhimurium to bind to lettuce leaves, revealing key structures like Lpf fimbriae and BapA.

From vacuole to cytosol - Disruptive invasion triggers cytosolic release of Salmonella Paratyphi A and subsequent cytosolic motility favors evasion of xenophagy

This study shows that Salmonella Paratyphi A escapes into the host cell cytosol through vacuole damage and uses flagella-mediated motility to evade xenophagy, aiding its survival and spread.

Intralumenal docking of Cx36 channels in the ER isolates mis-trafficked protein

The paper investigates how a dysfunctional PDZ binding motif in Cx36 affects its ER export and leads to ER retention and vesicle formation.

Single molecule analyses of Salmonella translocated effector proteins reveal targeting to and dynamics in host cell endomembranes

The paper uses single molecule analysis to study how Salmonella effector proteins reach and interact with host cell endomembranes, revealing dynamics and mechanisms of membrane remodeling.

Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium

This paper compares the intracellular transcriptomic profiles and phenotypes of Salmonella Paratyphi A and Salmonella Typhimurium during epithelial cell infection, identifying differences in flagella-chemotaxis, SPI-1, and carbon utilization pathways, and showing cytosolic motility and increased invasiveness of SPA.

A chemotactic sensor controls Salmonella-host cell interaction

The paper shows that the chemotactic sensor CheM controls Salmonella's ability to invade host cells by regulating the surface retention of the adhesin SiiE.

Single cell analyses reveal distinct adaptation of typhoidal and non-typhoidal Salmonella enterica serovars to intracellular lifestyle

This study compares the intracellular behavior of typhoidal and non-typhoidal Salmonella using single-cell analyses, revealing differences in SPI2-T3SS activity and protein biosynthesis.

Comprehensive single cell analyses of the nutritional environment of intracellular Salmonella enterica

This study uses dual fluorescence reporters to analyze the nutritional environment of intracellular Salmonella enterica in different host cells and niches, showing how the bacteria adapt and utilize host nutrients for proliferation.

Single cell analyses reveal phosphate availability as critical factor for nutrition of Salmonella enterica within mammalian host cells

This study shows that phosphate availability is critical for Salmonella enterica's intracellular replication, with the pstSCAB-phoU system mediating phosphate uptake in the Salmonella-containing vacuole.

The protected physiological status of intracellular Salmonella enterica persisters reduces host cell-imposed stress

The paper identifies that intracellular Salmonella enterica persisters have a protected physiological state that reduces host cell-imposed stress and supports recurrent infections.

Exposure to stressors and antimicrobials induces cell-autonomous ultrastructural heterogeneity of an intracellular bacterial pathogen

This study identifies ultrastructural morphotypes in Salmonella enterica serovar Typhimurium under stress and antimicrobial exposure, linking them to physiological states and stress responses.

Fluorescent protein-based reporters reveal stress response of intracellular Salmonella enterica on single cell level

The paper develops fluorescent protein-based reporters to monitor stress response and proliferation of intracellular Salmonella enterica at the single-cell level.

SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues

Recombinant protein production and purification of SiiD, SiiE and SiiF - components of the SPI4-encoded type I secretion system from Salmonella Typhimurium

The paper describes the recombinant production and purification of SiiD, SiiE, and SiiF proteins from Salmonella Typhimurium's SPI4 T1SS, with structural analysis of the resulting proteins.

Systematic analyses of factors required for adhesion of Salmonella enterica serovar Typhimurium to corn salad (Valerianella locusta)

This study identifies bacterial factors contributing to Salmonella Typhimurium adhesion to corn salad leaves using a reductionist approach.

A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella

This study identifies host factors involved in Salmonella-induced endosomal remodeling through an RNAi screen, revealing key roles for SNARE complexes, GTPases, and clathrin-coated structures.

Blocks in tricarboxylic acid cycle of Salmonella enterica cause global perturbation of carbon storage, motility and host-pathogen-interaction

This study shows that fumarase deficiency in Salmonella enterica disrupts carbon metabolism, leading to glycogen accumulation, altered motility, and increased macrophage phagocytosis.

Structural and functional characterisation of SiiA, an auxiliary protein from the SPI4-encoded type 1 secretion system from Salmonella enterica

This study characterizes SiiA, a T1SS subunit in Salmonella, showing its PG-binding and proton translocation functions and linking them to Salmonella invasion.

Characterization of a novel intratracheal aerosol challenge model of Brucella melitensis in guinea pigs

This paper establishes an intratracheal aerosol challenge model in guinea pigs to study Brucella melitensis infection, showing dose-dependent colonization and disease symptoms similar to human brucellosis.