Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue.
M. Bauza-Thorbrugge, E. Banke, B. Chanclon, E. Peris, Y. Wu, S. Musovic, C. Jonsson, P. Stralfors, P. Rorsman, C. S. Olofsson, I. W. Asterholm
This study shows that reducing SERCA2 in adipocytes impairs metabolic function, with white adipose tissue showing increased glucose uptake and brown adipose tissue showing reduced mitochondrial function.
bioRxiv · Mar 11, 2022Physiology