Author

P. Rorsman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Assay:electrophysiology· 2

Frequent Co-Authors

J. A. Kellard· 2 shared J. G. Knudsen· 2 shared L. Briant· 2 shared Y. Wu· 2 shared A. Bautista· 1 shared A. Benrick· 1 shared A. Clark· 1 shared A. F. Spigelman· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

J. A. Kellard

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Author profile →

6 papers

Recent·Most cited

Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model.

M. Jaffredo, N. A. J. Krentz, B. Champon, C. E. Duff, S. Nawaz, N. Beer, C. Honore, A. Clark, P. Rorsman, J. Lang, A. L. Gloyn, M. Raoux, B. Hastoy

This paper uses electrophysiological tools to functionally characterize iPSC-derived human β-like cells and assess the impact of a SLC30A8 variant on β-cell electrical coupling.

bioRxiv · Oct 17, 2023 · PreprintCell Biology

Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue.

M. Bauza-Thorbrugge, E. Banke, B. Chanclon, E. Peris, Y. Wu, S. Musovic, C. Jonsson, P. Stralfors, P. Rorsman, C. S. Olofsson, I. W. Asterholm

This study shows that reducing SERCA2 in adipocytes impairs metabolic function, with white adipose tissue showing increased glucose uptake and brown adipose tissue showing reduced mitochondrial function.

bioRxiv · Mar 11, 2022Physiology

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

X.-Q. Dai, J. Camunas-Soler, L. J. Briant, T. dos Santos, A. F. Spigelman, E. M. Walker, R. Arrojo e Drigo, A. Bautista, R. C. Jones, J. Lyon, A. Nie, N. Smith, J. E. Manning Fox, S. K. Kim, P. Rorsman, , P. E. MacDonald

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

bioRxiv · Apr 8, 2021Cell Biology

Release of insulin granules by simultaneous, high-speed correlative SICM-FCM

J. Bednarska, P. Novak, Y. Korchev, P. Rorsman, A. Tarasov, A. Shevchuk

This study uses SICM-FCM to directly observe insulin granule exocytosis in pancreatic β-cells, revealing the kinetics of vesicle fusion and insulin crystal solubilization.

bioRxiv · Sep 17, 2020Cell Biology

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet

J. A. Kellard, N. J. G. Rorsman, T. G. Hill, S. L. Armour, M. van der Bunt, P. Rorsman, J. G. Knudsen, L. Briant

This study shows that reduced somatostatin signaling in mice on a high fat diet leads to increased glucagon secretion, contributing to hyperglucagonaemia.

bioRxiv · Apr 7, 2020Cell Biology

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

A. Kim, J. G. Knudsen, J. C. Madara, A. Benrick, T. Hill, L. Abdul Kadir, J. A. Kellard, L. Mellander, C. Miranda, H. Lin, T. James, K. Suba, A. Spigelman, Y. Wu, P. MacDonald, , L. Briant

This study identifies arginine-vasopressin as a systemic regulator of glucagon secretion, showing its role in counter-regulatory responses to hypoglycemia and its impairment in type 1 diabetes.

bioRxiv · Jan 30, 2020Cell Biology