R. Channappanavar

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

This study shows that co-infection with SARS-CoV-2 and Klebsiella pneumoniae in mice leads to severe pneumonia and higher mortality.

This study shows that TLR7 signaling protects mice from lethal SARS-CoV-2 infection by enhancing antiviral responses and reducing inflammation.

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

This study shows that SARS-CoV-2 infection increases susceptibility and severity of secondary bacterial infection in mice, with time-dependent effects on immune responses and lethality.

This study identifies an effective two-dose IFN-lambda regimen that protects mice from lethal MERS-CoV infection by reducing viral load and inflammation.