Author

K. Pedram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. R. Bertozzi· 3 shared V. M. Weaver· 3 shared J. J. Northey· 2 shared N. M. Riley· 2 shared S. A. Malaker· 2 shared A. Fiore· 1 shared A. Kuo· 1 shared B. M. George· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiochemistry

C. R. Bertozzi

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Author profile →

5 papers

Recent·Most cited

Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore

A. Fiore, G. Yu, J. J. Northey, R. Patel, T. A. Ravenscroft, R. Ikegami, W. Kolkman, P. Kumar, J. B. Grimm, T. L. Dilan, V. M. S. Ruetten, M. B. Ahrens, H. Shroff, L. D. Lavis, S. Wang, , K. Pedram

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

bioRxiv · May 9, 2024 · PreprintBiochemistry

Expansion of in vitro Toxoplasma gondii cysts using enzymatically enhanced ultrastructure expansion microscopy

K. Bondarenko, F. Limoge, K. Pedram, M. Gissot, J. C. Young

This paper introduces an enzymatic digestion step using StcE to enable ultrastructure expansion microscopy of Toxoplasma gondii cysts, allowing detailed super-resolution analysis of the chronic infection stage.

bioRxiv · Apr 24, 2024 · PreprintMicrobiology

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

K. Pedram, D. J. Shon, G. S. Tender, N. R. Mantuano, J. J. Northey, K. J. Metcalf, S. P. Wisnovsky, N. M. Riley, G. C. Forcina, S. A. Malaker, A. Kuo, B. M. George, C. L. Miller, K. M. Casey, J. G. Vilches-Moure, , C. R. Bertozzi

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

bioRxiv · May 20, 2022Biochemistry

Revealing the human mucinome

S. A. Malaker, N. M. Riley, J. Shon, K. Pedram, V. Krishnan, O. Dorigo, C. R. Bertozzi

This study develops a mucinomics platform using an inactive mucinase to enrich and identify mucin-domain glycoproteins, revealing molecular signatures in cancer samples.

bioRxiv · Jan 27, 2021Biochemistry

A Bulky Glycocalyx Fosters Metastasis Formation by Promoting G1 Cell Cycle Progression

E. C. Woods, J. M. Barnes, M. W. Pickup, K. Pedram, F. Kai, M. J. Hollander, V. M. Weaver, C. R. Bertozzi

This study shows that a bulky glycocalyx promotes metastasis by enabling G1 cell cycle progression through integrin adhesion and signaling.

bioRxiv · Jun 28, 2017Cancer Biology