Author

C. Lenz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

H. Urlaub· 4 shared A. Bigot· 1 shared A. Boshnakovska· 1 shared A. C. Joerger· 1 shared A. D. Hofemeier· 1 shared A. Kraemer· 1 shared B. Foo· 1 shared B. Ross· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersBiochemistry

H. Urlaub

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Delta/+ mice hearts

B. Foo, H. Amedei, S. Kaur, S. Jaawan, A. Boshnakovska, T. Gall, R. A. de Boer, H. H. W. Sillje, H. Urlaub, P. Rehling, C. Lenz, S. E. Lehnart

bioRxiv · Mar 21, 2024Cell Biology

Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity

J. Gerninghaus, R. Zhubi, A. Kraemer, M. Karim, D. H. N. Tran, A. C. Joerger, C. Schreiber, L. M. Berger, B. T. Berger, T. A. L. Ehret, L. Elson, C. Lenz, K. Saxena, S. Mueller, S. Einav, , T. Hanke

The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.

bioRxiv · Feb 18, 2024 · PreprintBiochemistry

Uncovering the temporal dynamics and regulatory networks of thermal stress response in a hyperthermophile using transcriptomics and proteomics

F. Gruenberger, G. Schmid, Z. El-Ahmad, M. Fenk, K. Vogl, R. Reichelt, W. Hausner, H. Urlaub, C. Lenz, D. Grohmann

This study uses transcriptomics and proteomics to analyze the thermal stress response in Pyrococcus furiosus, revealing rapid transcriptome reprogramming and persistent protein upregulation during heat shock.

bioRxiv · May 2, 2023Microbiology

Dystrophin is a mechanical tension modulator

A. D. Hofemeier, M. Ristau, M. Luber, T. M. Muenker, F. Herkenrath, B. Schmelz, L.-M. Scharfenstein, M. Brandt, P. Malova, M. Shahriyari, M. Rinn, D. Haertter, M. Tiburcy, W. H. Zimmermann, C. Lenz, , T. Betz

This study shows that dystrophin modulates baseline homeostatic tension in skeletal muscle, linking increased tissue tension to DMD pathogenesis.

bioRxiv · Dec 23, 2022 · PreprintBiophysics

Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

M. Silva-Garcia, O. Bolgi, B. Ross, E. Pilla, K. Vijayalakshmi, M. Killisch, N. Stark, C. Lenz, M. Spitzner, M. D. Gorrell, M. Grade, H. Urlaub, M. Dobbelstein, R. Huber, R. Geiss-Friedlander

This study identifies DPP9 as a regulator of BRCA2 stability and DNA-damage repair by promoting its degradation via the N-degron pathway.

bioRxiv · Aug 24, 2020Biochemistry

SugarQuant: a streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics

P. Fang, Y. Ji, I. Silbern, C. Doebele, M. Ninov, C. Lenz, T. Oellerich, K.-T. Pan, H. Urlaub

SugarQuant provides a pipeline for site-specific N-glycoproteomics, enabling confident quantification of glycoforms in complex samples.

bioRxiv · May 20, 2020Biochemistry