ImmunologybioRxivPreprint
The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4+ T cell responses of older adults
H. Zhang, R. R. Jadhav, W. Cao…·J. Goronzy
The paper examines age-related changes in T cell responses by analyzing transcriptional and epigenetic profiles of naive CD4+ T cells from young and older adults, identifying increased epigenetic remodeling and effector cell differentiation.