Author

C. Neale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Assay:structural biology· 1

Frequent Co-Authors

A. E. Garcia· 1 shared A. G. Stephen· 1 shared A. H. Chan· 1 shared A. Malik· 1 shared A. Orazietti· 1 shared A. Pandey· 1 shared C. C. Gradinaru· 1 shared D. D. Fernandes· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

A. E. Garcia

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3 papers

Recent·Most cited

Ligand Modulation of the Conformational Dynamics of the A2A Adenosine Receptor Revealed by Single-Molecule Fluorescence

D. D. Fernandes, C. Neale, G.-N. W. Gomes, Y. Li, A. Malik, A. Pandey, A. Orazietti, X. Wang, L. Ye, S. Prosser, C. C. Gradinaru

This study uses single-molecule fluorescence to analyze how ligands modulate conformational dynamics of the A2A adenosine receptor, revealing ligand-dependent changes in state transitions and dynamics.

bioRxiv · Sep 20, 2020Biophysics

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

T. H. Tran, A. H. Chan, L. C. Young, L. Bindu, C. Neale, S. Messing, S. Dharmaiah, T. Taylor, J.-P. Denson, D. Esposito, D. V. Nissley, A. G. Stephen, F. McCormick, D. K. Simanshu

The paper determines crystal structures of KRAS mutants bound to RAF1 domains, revealing molecular interactions critical for RAS-mediated RAF activation.

bioRxiv · Jul 31, 2020Biophysics

The plasma membrane as a competitive inhibitor and positive allosteric modulator of KRas4B signaling

C. Neale, A. E. Garcia

The paper uses molecular dynamics simulations to show that anionic lipids influence Ras orientation, which affects its signaling competence and suggests a new drug target for Ras-driven cancers.

Biophysical Journal · Mar 1, 2020Peer-reviewedBiophysics