R. Watson

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

Mapping the planet's critical natural assets

The paper identifies critical natural assets that provide 90% of nature's contributions to people, showing their overlap with biodiversity and cultural diversity and their importance for sustainable development.

SARS-CoV-2-specific T cells associate with reduced lung function and inflammation in pulmonary post-acute sequalae of SARS-CoV-2

This study finds that elevated SARS-CoV-2-specific T cells in individuals with pulmonary PASC correlate with increased inflammation and reduced lung function.

Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis - Top-Down Mass Spectrometry (nCZE-TDMS)

The paper introduces nCZE-TDMS, a platform for separating and characterizing nucleosomes, histone subunits, and PTMs, and applies it to study histone modifications in cell lines with altered NSD2/MMSET expression.

How to fit in: The learning principles of cell differentiation

This paper develops a theoretical framework using logical functions and learning theory to model how cells integrate complex environmental cues during differentiation, revealing biases toward simpler plasticity functions that enhance adaptability.

The generation of a comprehensive spectral library for the analysis of the guinea pig proteome by SWATH-MS.

The paper generates a comprehensive spectral library for guinea pig proteome analysis using SWATH-MS, enabling improved quantitative proteomics in this model organism.