M. Price

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients.

This study identifies RHAMM as a marker of invasive niches in breast cancer, showing its association with poor outcomes and promoting invasion through a 27-gene signature.

The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancer

The paper shows that DDR heterogeneity in ovarian cancer predicts patient outcomes and chemotherapy response by analyzing DDR pathway interactions and constructing predictive DDR signatures.

Filling Gaps in Bacterial Amino Acid Biosynthesis Pathways with High-throughput Genetics

The paper identifies novel enzymes filling amino acid biosynthesis gaps in bacteria using genome-wide mutant fitness data, revealing previously unknown pathways for methionine, threonine, serine, and histidine synthesis.

A Cell Culture Platform For Cryptosporidium That Enables Long-Term Cultivation And New Tools For The Systematic Investigation Of Its Biology