Targeting TR4-induced RCC cells-derived exosomally initiated signaling increases Sunitinib efficacy
Z. Wang, Y. Sun, H. Xu, C. Huang, B. Cheng, F. Chou, B. You, X. Qiu, G. Yang, C. Chang
This study shows TR4 promotes RCC cell-derived exosomal ADAM15, which activates EGFR in endothelial cells and reduces Sunitinib efficacy, and demonstrates that targeting this pathway enhances Sunitinib effectiveness.
bioRxiv · Dec 7, 2022 · PreprintCancer Biology