C. Pohl

Beyond the biosynthetic gene cluster paradigm: Genome-wide co-expression networks connect clustered and unclustered transcription factors to secondary metabolic pathways

This study identifies six transcription factors regulating secondary metabolism in Aspergillus niger by analyzing co-expression networks across 155 growth conditions.

Reversible supramolecular assembly of the anti-microbial peptide plectasin into helical non-amyloid fibrils

The paper shows that a triple-mutant of plectasin forms reversible helical non-amyloid fibrils, with high-resolution structure and pH-dependent equilibrium.

Creating a bottleneck: Robust LC3B lipidation analysis by adjusting autophagic flux with low concentrations of Bafilomycin A1

The paper demonstrates that low concentrations of Bafilomycin A1 create a bottleneck for autophagic flux analysis, enabling effective discrimination of autophagy activators.

Planar cell polarity in the C. elegans embryo emerges by differential retention of aPARs at cell-cell contacts

This study shows how planar cell polarity in C. elegans embryos forms through asymmetric retention of aPARs at cell-cell contacts, involving Wnt signaling and Rho GTPases.

Uniaxial loading induces a scalable switch in cortical actomyosin flow polarization and reveals mechanosensitive regulation of cytokinesis

This study shows that uniaxial loading in C. elegans embryos switches cortical actomyosin flow polarization during cytokinesis, revealing mechanosensitive regulation of cytokinesis.

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

The paper presents the crystal structure of ULK2 with ATP inhibitors, identifies off-target effects of ULK1 inhibitors, and suggests structural insights for developing dual ULK1/2 inhibitors.