Author

E. Kandiah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

A. Grinzato· 2 shared A. A. Watson· 1 shared A. Fraudeau· 1 shared A. Houdusse· 1 shared A. L. Chambers· 1 shared A. Lanzavecchia· 1 shared A. Noergaard· 1 shared A. Round· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

A. Grinzato

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cryo-EM structure of the folded-back state of human β-cardiac myosin

A. Grinzato, D. Auguin, C. Kikuti, N. Nandwani, D. Moussaoui, D. Pathak, E. Kandiah, K. M. Ruppel, J. A. Spudich, A. Houdusse, J. Robert-Paganin

The paper reports the 3.6 Å cryo-EM structure of the folded-back IHM state of human β-cardiac myosin, revealing HCM mutation hotspots and structural differences from smooth muscle myosin IHMs.

bioRxiv · Apr 15, 2023 · PreprintBiophysics

The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane

J. Felix, L. Bumba, C. Liesche, A. Fraudeau, F. Rebeille, J. El Khoury, K. Huard, B. Gallet, C. Moriscot, J.-P. Kleman, Y. Duhoo, M. Jessop, E. Kandiah, F. Barras, J. Jouhet, I. Gutsche

This study identifies RavA and ViaA as modulators of E. coli aminoglycoside sensitivity through lipid interactions affecting membrane morphology and antibiotic resistance.

bioRxiv · Feb 6, 2022Microbiology

Reversible supramolecular assembly of the anti-microbial peptide plectasin into helical non-amyloid fibrils

C. Pohl, G. Effantin, E. Kandiah, S. Meier, G. Zeng, W. Streicher, G. H. Peters, G. Schoehn, C. Mueller-Dieckmann, A. Noergaard, P. Harris

The paper shows that a triple-mutant of plectasin forms reversible helical non-amyloid fibrils, with high-resolution structure and pH-dependent equilibrium.

bioRxiv · Sep 6, 2021 · PreprintBiophysics

Extremely potent human monoclonal antibodies for the prophylaxis and therapy of Tetanus

M. Pirazzini, A. Grinzato, D. Corti, S. Barbieri, O. Leka, F. Vallese, M. Tonellato, C. Silacci Fregni, L. Piccoli, E. Kandiah, G. Schiavo, G. Zanotti, A. Lanzavecchia, C. Montecucco

This study identifies two human monoclonal antibodies with high neutralizing activity against tetanus neurotoxin, showing potential for both prophylaxis and therapy.

bioRxiv · May 24, 2021Pathology

Cryo-EM structures reveal transcription initiation steps by yeast mitochondrial RNA polymerase

B. De Wijngaert, S. Sultana, C. Dharia, H. Vanbuel, J. Shen, D. vasilchuk, S. E. Martinez, E. Kandiah, S. S. Patel, K. Das

The paper uses cryo-EM to reveal steps of transcription initiation by yeast mitochondrial RNA polymerase, including promoter melting, template alignment, and abortive synthesis mechanisms.

bioRxiv · Apr 13, 2020Biophysics

Architecture of TAF11/TAF13/TBP complex suggests novel regulatory state in General Transcription Factor TFIID function

K. Gupta, A. A. Watson, T. Baptista, E. Scheer, A. L. Chambers, C. Koehler, J. Zou, I. Obong-Ebong, E. Kandiah, A. Temblador, A. Round, E. Forest, P. Man, C. Bieniossek, E. D. Laue, , I. Berger

The paper identifies a ternary TAF11/TAF13/TBP complex and reveals a novel regulatory state in TFIID function through structural and biochemical analyses.

bioRxiv · Jul 26, 2017Biochemistry