Author

C. R. Ethier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 3 Assay:imaging· 3 Organism:human· 2 Organism:rat· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. N. Safa· 6 shared A. J. Feola· 3 shared A. T. Read· 3 shared G. Li· 3 shared N. S. Fraticelli Guzman· 3 shared W. D. Stamer· 3 shared M. R. Bahrani Fard· 2 shared S. Farsiu· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersBioengineering

B. N. Safa

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A Method for Analyzing AFM Force Mapping Data Obtained from Soft Tissue Cryosections

C. A. Wong, N. S. Fraticelli Guzman, A. T. Read, A. Hedberg-Buenz, M. G. Anderson, A. J. Feola, T. Sulchek, C. R. Ethier

The paper describes an AFM force mapping pipeline to analyze mechanical properties of cryosectioned soft tissues, showing that repeated measurements, outlier exclusion, and log-normal transformation improve reliability.

bioRxiv · Nov 8, 2023Bioengineering

Aging and intraocular pressure homeostasis in mice

G. Li, J. van Batenburg-Sherwood, B. N. Safa, N. S. Fraticelli Guzman, A. Wilson, M. R. Bahrani Fard, K. Choy, M. L. de Ieso, S. Cui, A. J. Feola, T. Weisz, M. Kuhn, C. Bowes Rickman, S. Farsiu, C. R. Ethier, W. D. Stamer

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

bioRxiv · Oct 17, 2023Physiology

A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway

B. N. Safa, N. S. Fraticelli Guzman, G. Li, W. D. Stamer, A. J. Feola, C. R. Ethier

This study investigates the role of pectinate ligaments in maintaining the biomechanical stability of the aqueous outflow pathway in mice across different ages.

bioRxiv · Oct 17, 2023Bioengineering

The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study

B. N. Safa, A. Bleeker, J. P. Berdahl, C. R. Ethier

This study uses computational modeling to show that negative periocular pressure reduces optic nerve head strain and increases corneal strain, suggesting potential biomechanical benefits for glaucoma treatment.

bioRxiv · May 17, 2022Bioengineering

In vivo Biomechanical Assessment of Iridial Deformations and Muscle Contractions in Human Eyes

B. N. Safa, M. R. Bahrani Fard, C. R. Ethier

The paper assesses iridial biomechanical deformations and muscle contractions in human eyes using near-infrared movies from the pupillary light reflex to study their role in primary angle-closure glaucoma.

bioRxiv · Jan 14, 2022 · PreprintBioengineering

Assessment of the Viscoelastic Mechanical Properties of the Porcine Optic Nerve Head using Micromechanical Testing and Finite Element Modeling

B. N. Safa, A. T. Read, C. R. Ethier

This study measures the viscoelastic properties of porcine optic nerve heads using micromechanical testing and finite element modeling, revealing quadrant-specific mechanical characteristics.

bioRxiv · Apr 16, 2021Bioengineering

Identifiability of Tissue Material Parameters from Uniaxial Tests using Multi-start Optimization

B. N. Safa, M. H. Santare, C. R. Ethier, D. M. Elliott

This paper assesses the identifiability of tissue material parameters from uniaxial tests using synthetic data and multi-start optimization, finding that not all parameters are uniquely identifiable.

bioRxiv · Sep 9, 2020Bioengineering

Antifibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

G. Li, C. Lee, A. T. Read, K. Wang, I. Navarro, J. Cui, K. Young, R. Gorijavolu, T. Sulchek, C. Kopczynski, S. Farsiu, J. Samples, P. Challa, C. R. Ethier, W. D. Stamer

This study shows that netarsudil, a rho-kinase inhibitor, reverses glucocorticoid-induced ocular hypertension by reducing fibrosis and restoring outflow function.

bioRxiv · Jul 17, 2020Physiology

A Biphasic Approach for Characterizing Tensile, Compressive, and Hydraulic Properties of the Sclera

D. M. Brown, M. T. Pardue, C. R. Ethier

This paper measures biomechanical properties of sclera in pig and mouse using unconfined compression testing and poroelastic theory, showing comparable results to traditional methods and demonstrating the technique's applicability to mice.

bioRxiv · May 21, 2020Bioengineering