S. Cui

Aging and intraocular pressure homeostasis in mice

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Metabolic impact of trans 10, cis 12-conjugated linoleic acid on pai transgenic mice

This study investigates the long-term metabolic effects of t10c12-CLA in transgenic mice, finding increased brown fat and reduced white fat, along with elevated FGF21 and thermogenesis.

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

This study identifies HERC5-catalyzed ISGylation of cGAS as a mechanism that enhances antiviral innate immunity by modulating the cGAS-STING pathway.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

Cytokinins induce prehaustoria coordinately with quinone and phenolic signals in the parasitic plant Striga hermonthica

This study shows cytokinins act as haustorium-inducing factors in Striga hermonthica but not in Phtheirospermum japonicum, and their signaling pathway overlaps with quinone and phenolic pathways.

Strigolactones are chemoattractants for host tropism in Orobanchaceae parasitic plants

This study identifies strigolactones as chemoattractants guiding host tropism in parasitic Orobanchaceae plants.

Nitrates increase abscisic acid levels to regulate haustoria formation in the parasitic plant Phtheirospermum japonicum

This study shows nitrates inhibit haustoria formation in parasitic plants by increasing abscisic acid levels, with effects observed in both facultative and obligate parasites.

Acrylamide Fragment Inhibitors that Induce Unprecedented Conformational Distortions in Enterovirus 71 3C and SARS-CoV-2 Main Protease

The paper identifies acrylamide fragments that covalently inhibit EV71 3Cpro and SARS-CoV-2 Mpro by targeting their active site cysteine, inducing conformational changes and allosteric effects.

Mechanism of duplex unwinding by coronavirus nsp13 helicases

This paper investigates the unwinding mechanism of coronavirus nsp13 helicases using single-molecule FRET, revealing distinct step sizes and NTP hydrolysis patterns between MERS-CoV and SARS-CoV-2 nsp13.

Binding of the SARS-CoV-2 Spike Protein to Glycans

This study compares the binding of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins to glycans, finding HS binding is sulfation-dependent and sialic acid binding is absent.

Three-dimensional reconstructions of the internal structures of haustoria in parasitic Orobanchaceae

Three-dimensional image reconstruction was used to visualize the spatial organization of cell types in the haustoria of parasitic plants with special reference to their interaction with host roots.

Residue retention promotes soil carbon accumulation in minimum tillage systems: Implications for conservation tillage

This study finds that combining minimum tillage with residue retention in double cropping systems most effectively increases soil carbon storage.