J. X. Jiang

Basophils drive the resolution and promote wound healing in adult and aged mice

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

Benchmarking organ-specific responses to therapies in tissues differentiated from Cystic Fibrosis patient derived iPSCs

This study benchmarks Trikafta's efficacy in CF patient-derived iPSC-derived colonic and airway tissues compared to isogenic controls, showing differential therapeutic responses.

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

This study compares a novel CFTR potentiator, SK-POT1, to ivacaftor in improving mucociliary clearance in airway epithelial cells exposed to cigarette smoke.

Connexin 43 Hemichannels Regulate Mitochondrial ATP Generation, Mobilization, and Mitochondrial Homeostasis against Oxidative Stress

This study shows that mitochondrial Cx43 hemichannels regulate mitochondrial ATP production and protect osteocytes from oxidative stress by facilitating ion and ATP transfer and interacting with ATP synthase.

Bone marrow AdipoQ-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis and bone mass

The paper identifies bone marrow AdipoQ-lineage progenitors as a major source of M-CSF, showing their critical role in macrophage development, osteoclastogenesis, and bone mass regulation.

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

Three-dimensional mapping identifies distinct vascular niches for myelopoiesis

This paper maps 3D vascular niches for myeloid differentiation in bone marrow, revealing distinct spatial organization of granulocyte and monocyte/dendritic cell progenitors.