Author

C.-Y. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Assay:proteomics· 2

Frequent Co-Authors

C.-P. Chen· 3 shared K.-Y. A. Huang· 3 shared S.-H. Cheng· 3 shared S.-R. Shih· 3 shared T.-Y. Lin· 3 shared Y.-C. Huang· 3 shared Y.-C. Lin· 3 shared A. Townsend· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

C.-P. Chen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

VPS8D, a CORVET subunit, is required to maintain the contractile vacuole complex in Tetrahymena thermophila

C.-Y. Cheng, J. Hernandez, A. Turkewitz

This paper shows that VPS8D, a CORVET subunit in Tetrahymena thermophila, is essential for maintaining the contractile vacuole complex (CVC) structure and function, as its knockdown leads to disassembly of CVC components and increased osmotic sensitivity.

bioRxiv · Nov 7, 2023 · PreprintCell Biology

Structure and dynamics of the contractile vacuole complex in Tetrahymena thermophila

C.-Y. Cheng, D. P. Romero, M. Zoltner, M.-C. Yao, A. Turkewitz

The paper identifies four proteins that localize to distinct zones of the contractile vacuole complex in Tetrahymena thermophila, enabling in vivo analysis of its dynamics and structure.

bioRxiv · Sep 13, 2023 · PreprintCell Biology

Anti-spike antibody response to natural infection with SARS-CoV-2 and its activity against emerging variants

C.-P. Chen, K.-Y. A. Huang, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, Y.-C. Huang, T.-Y. Lin, S.-H. Cheng

This study examines spike-specific antibody responses in SARS-CoV-2 natural infections, showing waning immunity over 11 months and reduced activity against emerging variants like Beta and Omicron.

bioRxiv · Mar 7, 2022Immunology

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

K.-Y. A. Huang, T. Tan, T.-H. Chen, C.-G. Huang, R. Harvey, S. Hussain, C.-P. Chen, A. Harding, J. Gilbert-Jaramillo, X. Liu, M. Knight, L. Schimanski, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, , A. Townsend

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

D. Zhou, H. M. E. Duyvesteyn, C.-P. Chen, C.-G. Huang, T.-H. Chen, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, S.-H. Cheng, Y.-C. Huang, T.-Y. Lin, C. Ma, J. Huo, L. Carrique, T. Malinauskas, , K.-Y. A. Huang

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

bioRxiv · Jun 12, 2020Microbiology

Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells

C.-Y. Cheng, Z. Zhou, M. Stone, B. Lu, A. Flesken-Nikitin, D. M. Nanus, A. Y. Nikitin

This study shows MME suppresses prostate cancer by inhibiting GRP/GRPR signaling in stem/progenitor cells, and identifies GRPR as a therapeutic target in MME-low cancers.

bioRxiv · Dec 23, 2019Cancer Biology

Characterization of Single Protein Dynamics in Cell Plasma Membrane Derived Polymer Cushioned Lipid Bilayers

W. C. Wong, J.-Y. Juo, Y.-H. Liao, C.-Y. Cheng, C.-H. Lin, C.-L. Hsieh

This study characterizes single membrane protein dynamics in polymer-cushioned lipid bilayers and finds that increasing polymer length enhances protein mobility and reduces transient confinement.

bioRxiv · May 17, 2019 · PreprintBiophysics