A. Chopra

Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson Syndrome and Toxic epidermal necrolysis.

The paper uses multiomic single-cell sequencing to analyze SJS/TEN patients' skin and blister fluid, identifying tissue-specific immune responses and T-cell clonotypes involved in pathogenesis.

CD3+ T-cell: CD14+monocyte complexes are dynamic and increased with HIV and glucose intolerance

The paper identifies increased CD3+ T-cell:CD14+ monocyte complexes in diabetes and HIV, associated with inflammation and metabolic changes.

The Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening

The paper introduces the Halo Library, a set of halogenated fragments that improves the success rate of X-ray crystallographic fragment screening by identifying binding sites and hot spots on proteins.

Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

This study shows that anti-RBDwt titers correlate with neutralizing antibody levels against multiple SARS-CoV-2 variants and proposes a method to improve immunomonitoring precision and throughput.

Evaluation of the antimicrobial, anti-adhesion, anti-biofilm and cell proliferation assay of a de-novo goji berry extract against periodontal pathogens: a comparative in-vitro study

This study evaluates the antimicrobial, anti-adhesion, anti-biofilm, and cytotoxic properties of a goji berry extract against periodontal pathogens in vitro, finding it comparable to chlorhexidine but less effective than doxycycline.

Balanced chromosomal rearrangements offer insights into coding and noncoding genomic features associated with developmental disorders

The paper analyzes balanced chromosomal rearrangements in developmental disorders, finding noncoding variants disrupt TADs and contribute to pathogenic long-range positional effects.

Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome

This paper shows anti-asprosin monoclonal antibodies reduce appetite, body weight, and blood glucose in metabolic syndrome mouse models.

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

Proteome-wide Prediction of Lysine Methylation Reveals Novel Histone Marks and Outlines the Methyllysine Proteome

The paper predicts lysine methylation sites using MethylSight and validates them with mass spectrometry, identifying 70 new histone marks and 50,000 non-histone sites.

Global biogeography since Pangaea

The paper tests if molecular clock dates of vertebrate speciation events align with palaeomagnetic dates of continental separations after Pangaea's breakup.