Author

J. A. Boyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Q. Zhang· 2 shared A. Barlas· 1 shared A. M. Goddard· 1 shared A. Y. Ho· 1 shared B. Zhao· 1 shared C. E. Foster· 1 shared C. Fan· 1 shared c. J. perou· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Q. Zhang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

s. gadal, J. A. Boyer, S. F. Roy, N. A. Outmezguine, M. Sharma, H. Li, N. Fan, E. Chan, Y. Romin, A. Barlas, Q. Chang, P. Pancholi, N. M. Timaul, M. Overholtzer, R. Yaeger, , N. Rosen

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

bioRxiv · Nov 21, 2023 · PreprintCancer Biology

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

M.-G. Cho, R. J. Kumar, C.-C. Lin, J. A. Boyer, J. A. Shahir, K. Fagan-Solis, D. A. Simpson, C. Fan, C. E. Foster, A. M. Goddard, Q. Wang, Y. Wang, A. Y. Ho, P. Liu, c. J. perou, , G. P. Gupta

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

bioRxiv · Dec 9, 2022Cell Biology

Visualizing a protonated RNA state that modulates microRNA-21 maturation

J. T. Baisden, J. A. Boyer, B. Zhao, Q. Zhang

The paper identifies a pH-dependent structural dynamic in pre-miR-21 that enhances Dicer processing through a protonated A+-G mismatch.

bioRxiv · Nov 23, 2019Biophysics