M. Pandey

Disruption of IL-17 signaling in the respiratory mucosa results in invasive streptococcal infection

This study shows that IL-17 deficiency in mice leads to increased S. pyogenes dissemination after respiratory infection, contributing to invasive streptococcal disease.

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

This study shows that the VapC12 toxin in Mycobacterium tuberculosis modulates host immune responses, promoting pathogen survival by altering T-cell and neutrophil responses.

Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

The paper identifies SEL1L as a regulator of collagen turnover through a negative feedback loop, showing its role in limiting collagen accumulation in fibrotic lung disease.

MAP Kinase and mammalian target of rapamycin are main pathways of gallbladder carcinogenesis: Results from bioinformatic analysis of Next Generation Sequencing data from a hospital-based cohort.

The paper identifies MAP kinase and mTOR pathways as key drivers of gallbladder carcinogenesis through bioinformatic analysis of NGS data from a hospital-based cohort.

A phasevarion controls multiple virulence traits, including expression of vaccine candidates, in Streptococcus pneumoniae

This study shows that the SpnIII phasevarion in S. pneumoniae affects multiple virulence traits and vaccine candidate expression, highlighting its importance in vaccine design.

Flagellar targeting of an arginine kinase requires the conserved Lipidated Intraflagellar Transport (LIFT) pathway in Trypanosoma brucei

This study identifies TbUnc119 as a myristoylated cargo carrier in Trypanosoma brucei, showing its role in targeting the arginine kinase TbAK3 to the flagellum via the conserved LIFT pathway.

Effect of dioxins in milk on 3D-cultured primary buffalo granulosa cells, a pilot study for a prospective RT-LAMP colour reaction for dioxin toxicity

The paper tests a 3D-cultured buffalo granulosa cell-based RT-LAMP colour reaction to detect dioxin toxicity in milk, finding AHR expression as a potential marker.

Host cholesterol dependent activation of VapC12 toxin enriches persister population during Mycobacterium tuberculosis infection

This study identifies cholesterol-dependent activation of the VapC12 toxin in Mycobacterium tuberculosis as a mechanism that increases persister formation during infection.

Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss

The paper identifies deamidation at Asn-358 in moxetumomab pasudotox causing conformational changes and reduced immunotoxin activity.

Carbohydrate, glutathione, and polyamine metabolism are central to Aspergillus flavus oxidative stress responses over time

This paper identifies metabolite pathways involved in oxidative stress responses of Aspergillus flavus over time, linking them to aflatoxin production and stress tolerance.