D. Alsteens

Plasma membrane nanodeformations promote actin polymerisation through CIP4/CDC42 recruitment and regulate type II IFN signaling

The paper investigates how plasma membrane nanodeformations influence actin polymerization and type II IFN signaling via CIP4/CDC42 recruitment.

AFM-based force spectroscopy unravels the stepwise-formation of a DNA transposition complex driving multi-drug resistance dissemination

The paper uses atomic force microscopy to study the stepwise formation of a DNA transposition complex involved in antibiotic resistance dissemination.

The human neuronal receptor NgR1 bridges reovirus capsid proteins to initiate infection

This study identifies how NgR1 bridges reovirus capsid proteins to initiate infection, revealing a unique binding interface and its role in virus entry and receptor ligand interactions.

Reovirus σ1 conformational flexibility modulates the efficiency of host cell attachment

This study shows that conformational flexibility of reovirus σ1 protein affects host cell attachment efficiency by engineering cysteine mutations that alter σ1 structure.

High-affinity agonist binding to C5aR results from a cooperative two-site binding mechanism

This study identifies a cooperative two-site binding mechanism for C5aR activation using atomic force microscopy, steered molecular dynamics, and functional assays.