M. Koehler

Glioma-associated tertiary lymphoid structures are sites of lymphocyte clonal expansion and plasma cell formation

The paper identifies tertiary lymphoid structures in gliomas as sites of immune response, showing they correlate with better survival and involve T and B cell clonal expansion and plasma cell formation.

The cohesin subunit RAD21.2 functions as a recombination silencer of ribosomal DNA arrays

The paper identifies RAD21.2 as a repressor of meiotic recombination at rDNA regions in Arabidopsis, contributing to genome stability across generations.

The human neuronal receptor NgR1 bridges reovirus capsid proteins to initiate infection

This study identifies how NgR1 bridges reovirus capsid proteins to initiate infection, revealing a unique binding interface and its role in virus entry and receptor ligand interactions.

Reovirus σ1 conformational flexibility modulates the efficiency of host cell attachment

This study shows that conformational flexibility of reovirus σ1 protein affects host cell attachment efficiency by engineering cysteine mutations that alter σ1 structure.

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes

This study determines the stoichiometry and topology of nsp7+8 complexes from seven coronaviruses using mass spectrometry and biophysical techniques, revealing three clustering groups with distinct assembly patterns.

High-affinity agonist binding to C5aR results from a cooperative two-site binding mechanism

This study identifies a cooperative two-site binding mechanism for C5aR activation using atomic force microscopy, steered molecular dynamics, and functional assays.