Author

D. Clement

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

A. Pfefferle· 2 shared B. Jacobs· 2 shared J. P. Goodridge· 2 shared K.-J. Malmberg· 2 shared M. T. Wiiger· 2 shared S. Lorenz· 2 shared A. Brech· 1 shared C. Grimm· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. Pfefferle

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Author profile →

2 papers

Recent·Most cited

Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal

B. Jacobs, A. Pfefferle, D. Clement, J. P. Goodridge, M. L. Saetersmoen, S. Lorenz, M. T. Wiiger, K.-J. Malmberg

The paper shows that IL-15 withdrawal induces apoptosis in NK cells by increasing BIM short splice variant expression, linked to caspase-3 activation and cell death.

bioRxiv · Aug 17, 2018Immunology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology