Author

T. Clancy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Approach:deep learning· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Research Focus:clustering· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Pfefferle· 4 shared J. P. Goodridge· 4 shared K.-J. Malmberg· 4 shared E. H. Ask· 3 shared E. Sohlberg· 3 shared S. Lorenz· 3 shared B. Jacobs· 2 shared A. Brech· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersImmunology

A. Pfefferle

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Author profile →

5 papers

Recent·Most cited

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

H. K. Netskar, A. Pfefferle, J. P. Goodridge, E. Sohlberg, O. Dufva, S. Teichmann, T. Clancy, a. horowitz, K.-J. Malmberg

The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.

bioRxiv · Oct 26, 2023Immunology

The T cell epitope landscape of SARS-CoV-2 variants of concern

S. Tennoe, M. Gheorghe, R. Stratford, T. Clancy

This study uses an AI platform to analyze T cell epitopes across SARS-CoV-2 variants, showing consistent protection across mutated peptides and common HLA alleles.

bioRxiv · Jun 6, 2022Immunology

A Temporal Transcriptional Map of Human Natural Killer Cell Differentiation

A. Pfefferle, H. Netskar, E. H. Ask, S. Lorenz, J. P. Goodridge, E. Sohlberg, T. Clancy, K.-J. Malmberg

This study maps the transcriptional changes during human NK cell differentiation using single-cell RNA sequencing, identifying key gene programs and checkpoints.

bioRxiv · May 7, 2019 · PreprintImmunology

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity

A. Pfefferle, B. Jacobs, E. H. Ask, S. Lorenz, T. Clancy, J. P. Goodridge, E. Sohlberg, K.-J. Malmberg

The paper uses flow cytometry and single-cell RNA sequencing to show intra-lineage plasticity and functional reprogramming maintain NK cell repertoire diversity during IL-15-driven homeostasis.

bioRxiv · Jan 9, 2019Immunology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology