Author

E. H. Ask

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:flow cytometry· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

K.-J. Malmberg· 4 shared A. Pfefferle· 3 shared J. P. Goodridge· 3 shared S. Lorenz· 3 shared T. Clancy· 3 shared B. Jacobs· 2 shared E. Sohlberg· 2 shared A. Brech· 1 shared

Activity by Year

2018-2023 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

K.-J. Malmberg

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4 papers

Recent·Most cited

MetaGate: Interactive Analysis of High-Dimensional Cytometry Data with Meta Data Integration

E. H. Ask, A. Tschan-Plessl, H. J. Hoel, A. Kolstad, H. Holte, K.-J. Malmberg

MetaGate integrates clinical metadata with high-dimensional cytometry data for interactive statistical analysis and visualization of immune cell populations in DLBCL patients.

bioRxiv · Oct 27, 2023 · PreprintImmunology

A Temporal Transcriptional Map of Human Natural Killer Cell Differentiation

A. Pfefferle, H. Netskar, E. H. Ask, S. Lorenz, J. P. Goodridge, E. Sohlberg, T. Clancy, K.-J. Malmberg

This study maps the transcriptional changes during human NK cell differentiation using single-cell RNA sequencing, identifying key gene programs and checkpoints.

bioRxiv · May 7, 2019 · PreprintImmunology

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity

A. Pfefferle, B. Jacobs, E. H. Ask, S. Lorenz, T. Clancy, J. P. Goodridge, E. Sohlberg, K.-J. Malmberg

The paper uses flow cytometry and single-cell RNA sequencing to show intra-lineage plasticity and functional reprogramming maintain NK cell repertoire diversity during IL-15-driven homeostasis.

bioRxiv · Jan 9, 2019Immunology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology