B. Jacobs

Protoxylem microtubule patterning requires ROP pattern co-alignment, realistic microtubule-based nucleation, and sufficient microtubule flexibility.

This study identifies the requirements for protoxylem microtubule band formation using simulations, showing that flexibility, ROP co-alignment, and microtubule-based nucleation are essential.

Consequences of alternative stable states for short-term model-based control of cyanobacterial blooms

The paper examines model-based strategies for mitigating cyanobacterial blooms in lakes with alternative stable states, evaluating their effectiveness and costs.

Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver Cancers

This study characterizes Morreton virus (MORV) as a safe and effective oncolytic virotherapy for liver cancers, showing tumor regression in animal models with lower doses than VSV.

Multi-modal Efficacy of a Chimeric Vesiculovirus Expressing the Morreton Glycoprotein in Sarcoma

This study develops a chimeric vesiculovirus (VMG) expressing MorV glycoprotein, showing anti-tumor effects in sarcoma models with in vitro efficacy and in vivo tumor reduction.

Treatment with anti-inflammatory viral serpin modulates immuno-thrombotic responses and improves outcomes in SARS-CoV-2 infected mice

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

Nucleation complex behaviour is critical for cortical microtubule array homogeneity and patterning

This study shows that limited nucleation complex recruitment to microtubules balances positive feedback, enabling cortical microtubule array patterning in plant cells.

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins

This paper investigates the structural interactions of the BRD3 ET domain with host and viral proteins, revealing polymorphic structural interfaces and conformational plasticity.

Robust banded protoxylem pattern formation through microtubule-based directional ROP diffusion restriction

The paper investigates how ROP proteins and microtubules interact to form banded protoxylem patterns in plants, showing that microtubules act as directional diffusion barriers.

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity

The paper uses flow cytometry and single-cell RNA sequencing to show intra-lineage plasticity and functional reprogramming maintain NK cell repertoire diversity during IL-15-driven homeostasis.

Small GTPase patterning: How to stabilise cluster coexistence

This paper investigates mechanisms for stable coexistence of multiple small GTPase clusters and shows how two modifications—GTPase turnover or negative feedback—enable dynamic patterning in biological processes.

Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal

The paper shows that IL-15 withdrawal induces apoptosis in NK cells by increasing BIM short splice variant expression, linked to caspase-3 activation and cell death.

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.