J. Ferguson

CTCF regulates hepatitis B virus cccDNA chromatin topology

This study shows that CTCF regulates HBV cccDNA chromatin topology and nucleosomal positioning, affecting viral transcription.

Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines

The paper introduces a triple tandem trimer (TTT) design for HIV-1 Env and influenza HA immunogens, showing improved trimer-specific immune responses in viral vectored vaccines.

Increasing environmental fluctuations can dampen variability of endogenously cycling populations

The paper shows that increasing environmental variability can reduce population variance in endogenously cycling populations, challenging existing models that predict increased variability.

The p-rpS6-zone delineates wounding response and the healing process

The paper identifies a p-rpS6-zone around wounds that marks the healing process and shows its role in tissue repair.

Spatially Resolved Phosphoproteomics Reveals Fibroblast Growth Factor Receptor Recycling-driven Regulation of Autophagy and Survival

The paper uses spatially resolved phosphoproteomics to show FGFR2b recycling activates mTOR and ULK1, suppressing autophagy and promoting cell survival in cancer cells.

Symbiotic bacterial community of Drosophila melanogaster changes with nutritional modifications of the diet but can alleviate negative effects on larval phenotypes

This study shows that dietary changes in Drosophila melanogaster alter their gut microbiota composition and can be mitigated by symbiotic bacteria, improving larval survival and reducing triglyceride levels.

The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression

This paper shows CTCF regulates HPV18 transcript splicing and late gene expression during differentiation by controlling chromatin looping and splice site usage.

Reciprocal Priming between RTKs at Recycling Endosomes Orchestrates Cellular Signaling Outputs

The paper identifies reciprocal priming between FGFRs and EGFR at recycling endosomes that coordinates signaling outputs in breast cancer cells.

Machine learning enabled phenotyping for GWAS and TWAS of WUE traits in 869 field-grown sorghum accessions

This study uses machine learning and phenotyping to identify 394 genes associated with water use efficiency traits in sorghum through GWAS and TWAS of 869 field-grown accessions.

The CCCTC-binding factor CTCF represses hepatitis B virus Enhancer I and regulates viral transcription

This study identifies CTCF as a repressor of HBV transcription by binding to Enhancer I and reducing pre-genomic RNA levels.

Emergence of Lyme disease on treeless islands in Scotland, UK

This study examines Lyme disease emergence on treeless islands in Scotland, finding higher tick prevalence and human exposure linked to increased incidence.

Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation

The paper uses live cell imaging to show clathrin-coated pits develop curvature early without requiring a flat-to-curved transition.