Author

R. Iacone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Cortes Cabrera· 1 shared A. Flohr· 1 shared A. Mayweg· 1 shared A. Salomatov· 1 shared A. Topp· 1 shared B. Banfai· 1 shared C. Stucki· 1 shared C.-y. Chen· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. Cortes Cabrera

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Author profile →

2 papers

Recent·Most cited

EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By Erlotinib

E. Buck, M. O'Connor, D. Romashko, A. Salomatov, N. Ishiyama, D. Epstein, A. Mayweg, A. Flohr, R. Iacone, T. Nicolaides, S. Markovic, J. Zhang

The paper identifies a mechanism by which extracellular domain EGFR mutations in glioblastoma are activated through covalent dimerization, rendering ATP-site inhibitors ineffective and paradoxically promoting proliferation.

bioRxiv · Oct 21, 2019 · PreprintCancer Biology

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

A. Cortes Cabrera, E. Melo, D. Roth, A. Topp, F. Delobel, C. Stucki, C.-y. Chen, P. Jakob, B. Banfai, T. Dunkley, O. Schilling, S. Huber, R. Iacone, P. Petrone

This study elucidates the allosteric mechanism of HtrA1 activation through inter-monomer communication, showing its role in proteolytic activity and disease-related pathologies.

bioRxiv · Jul 14, 2017Biophysics